This study compared and analyzed indigenous and modern agricultural technologies used in cassava production in Anambra State. Multi-stage sampling technique was used in sample selection. A total of 160 farmers were purposively selected from the four Agricultural zones that made up the state based on the use of modern and indigenous technologies. Data were collected using structured questionnaire. Descriptive statistics and total factor productivity were used in analyzing the data. The result of the analysis showed that both categories of farmers are within the working class age bracket of 40 and 60 years. The modern technology users were found to be more educated, have larger farm holding and higher average income per hectare than their counterparts. Farmers that used indigenous technologies have larger household size than those that used modern technologies. The total factor productivity (TFP) ratios computed for modern and indigenous technology users are 1.493 and 0.758 respectively. Sequel to the fact that the Z-calculated was higher than the Z-tabulated, the null hypothesis was rejected. This implies that there was a statistically significant difference between the productivity of farmers that used modern technologies and those that used indigenous technologies. The F-ratio also tested confirmed the higher variance in TFP for the two categories of farmers which shows a higher significant difference in the mean values. It was therefore concluded that the use of modern technologies in cassava production should be encouraged because they ensure higher agricultural productivity among farmers. [Nwaiwu et al. Comparative Analysis of Productivity of Cassava Based Crop Mixture under Modern and Indigenous Technologies in Anambra State, Nigeria. International Journal of Agricultural Science, Research and Technology, 2012; 2(1):17-21].